Syringe Filters, 25mm, Nylon, w/ Multi-Depth Pre Filters, 0.45um Final Pore Size. Black with White Polypropylene, AQ Brand. 1000/CS.
Additional Info:
The 58045-NDX-CASE AQ™ Syringe Filters are pharmaceutical-grade, high-throughput membrane filters engineered for HPLC sample preparation and dissolution testing in regulated laboratory environments, specifically for samples with high particulate load. These filters incorporate a three-layer, binder-free borosilicate micro glass fiber prefilter system, paired with a 0.45 µm Nylon‑66 final membrane, delivering exceptional throughput, reduced clogging, and extractable-free performance.
This multi-depth filtration system dramatically increases dirt-holding capacity, allowing efficient processing of difficult, viscous, or particulate-heavy samples without premature clogging, making it ideal for high-volume QC/QA workflows.
✅ Critical Compliance Advantage (No Flush Required)
These filters are validated and certified to meet stringent regulatory requirements, including:
US FDA CFR Title 21, Part 210.3(b)(6) for minimum fiber release
USP <788> for particulate matter in injectables
USP requirements for “Sterile Water for Injection”
Because of this validated performance:
✅ No initial flushing is required
✅ No need to discard the first 200 µL of filtrate
✅ Preserves valuable samples
✅ Eliminates a common cause of failed methods and investigations
👉 This delivers a major operational and compliance advantage for QC/QA laboratories, especially when working with complex or particulate-rich matrices where reproducibility and efficiency are critical.
Performance & Design
The three-layer glass fiber prefilter system removes larger particulates prior to final membrane filtration, significantly reducing clogging and improving flow consistency across high-throughput workflows.
The 0.45 µm Nylon‑66 membrane is optimized for sample clarification and prefiltration, offering high flow rates with ultra-low adsorption, even for charged analytes.
The advanced 16-channel outlet design minimizes back pressure, enabling smooth filtration with reduced hand force, improving ergonomics and productivity in repetitive laboratory processes.
The 25 mm format supports higher sample volumes, and the bulk 1000/case packaging is ideal for high-throughput labs and production-scale analytical environments.
The black housing with grey lettering provides clear identification of multi-depth 0.45 µm nylon filters, and each case includes a Certificate of Analysis to support full compliance and traceability.
Key Features
Multi‑Depth Prefilter System (3 Layers)
Binder-free borosilicate glass fiber
Handles high particulate loads
Extends filter life and prevents clogging
0.45 µm Nylon‑66 Final Membrane (Pharma Grade)
Ideal for clarification and prefiltration
High consistency for validated methods
✅ No Initial Flush Required (Validated)
Extractable-free from first filtrate
No 200 µL discard required
High Throughput Performance
Designed for difficult or particulate-heavy samples
Improves workflow efficiency
Ultra-Low Adsorption
Suitable for sensitive and charged analytes
Maximizes analyte recovery
Advanced 16-Channel Outlet Design
Reduces back pressure
Requires less hand force
Regulatory Compliance
Meets FDA CFR Title 21 requirements
Complies with USP <788>
Suitable for Sterile Water for Injection
25 mm Diameter for High Throughput
Handles larger volumes
Ideal for routine and production workflows
Autoclavable & EO Sterilizable
121°C for 30 minutes or Ethylene Oxide
Color-Coded (Black / Grey)
Identifies multi-depth 0.45 µm nylon filters
Bulk Packaging (1000/Case)
Reduces cost per analysis
Ideal for high-throughput QC environments
Typical Applications
HPLC & UHPLC Sample Preparation – particulate-heavy sample clarification
Biological & Complex Samples – multi-stage filtration required
Dissolution Testing – pharmaceutical QC workflows
Environmental & Food Analysis – high particulate matrices
Regulated Laboratory Methods – validated, compliant processes
High-Throughput Labs – reduced clogging and increased productivity
Specifications
Filter Type: Syringe Filter with Multi-Depth Prefilters (Pharma Grade)
Membrane Material: Nylon‑66
Prefilter Material: Binder-Free Borosilicate Glass Fiber (3 layers)
Pore Size (Final Membrane): 0.45 µm
Diameter: 25 mm
Housing Material: Polypropylene (PP)
Color Code: Black / Grey (Multi-depth 0.45 µm Nylon)
Connection Type: Luer Lock / Slip
Chemical Compatibility: Aqueous and organic solvents
Extractables: None detectable (no flush required)
Sterilization: Autoclave or EO
Compliance: FDA CFR 21, USP <788>
Certification: Certificate of Analysis included
Sterility: Non-sterile
Pack Size: 1000/Case
Brand: AQ™
Resources & Ordering Options
View detailed product specifications for 58045‑NDX‑CASE
Purchase multi-depth nylon syringe filters, 0.45 µm, 25 mm – 100/pack quantity
Order multi-depth nylon syringe filters, 0.45 µm, 25 mm – 50/pack quantity
Click HERE for 100 in a package quantity or Click HERE for 50 in a package quantity.